Lucie Harris Locke was born in Georgia. Her father, a medical doctor, sought his fortune in the mining camps of the West and moved his family to El Paso in 1916. She graduated from El Paso High School. She later attended Sophie Newcomb College and El Paso Jr. College. In 1921-1924, and again in 1932, she studied with Xavier Gonzalez, Ellsworth Woodward and Will Henry Stevens at Sophie Newcomb College, in New Orleans. She also studied with Charles Resent and Olin Travis at the Witte Museum Art School, and with Frederic Taubes, Stella Shurtleff and Increase Robinson. After marriage to her husband, a mining engineer, she lived in  Mexico and San Antonio until settling in Corpus Christi in 1934. In the late 1940s she developed an allergy to oil paint and was forced to work in watercolors, casein and black and white. She was an art critic for the "Corpus Christi Caller-Times from 1945-1958. In 1949 she wrote and illustrated "Naturally Yours, Texas", a book of poetry. She was a founding member of the South Texas Art League and the CC Art Foundation and worked to establish an art museum in Corpus Christi.  She had a long and productive career and was an innovative part of the South Texas art movement.

Exhibited: San Antonio Local 1930 – 1936, 1940-1941; TFAA 1933 – 1958, 1963 - 1969 New Orleans AA 1934 – 1948; Witte Memorial Museum 1935 (solo); La Retama Library, Corpus Christi 1936 (solo), 1937 ; HMFA SE Texas Exhibition, 1937, 1939, Bright Shawl Gallery 1939 (solo); Texas-Oklahoma General 1941; Corpus Christi 1942 (solo); Eagle Pass International Exposition 1942, Caller Times Exhibition, 1943-1947, National League of American Pen Women came after the Washington, D.C. 1946; South Texas AL 1935-1958; Southern States Art League 1931 – 1946; Texas General 1944-1946; Corpus Christi Art Foundation 1945 – 1958; Federated Garden Clubs Houston 1948 (solo); Pan American Galleries, San Antonio 1948 (solo); CC Centennial Museum 1949 (solo); South Texas Fair Kingsville 1948; Texas A&I, Kingsville 1947 (solo); Museum New Mexico 1949; Terry Art Institute, 1952; TWCS Annual 1950, 1952; Texas Fed. Women’s Clubs Austin 1954 (solo); Corpus Christi Community Center Exhibition 1973.

Member: Texas Watercolor Society; Texas Fine Arts Association; American Federation of Arts; Corpus Christi Art Foundation; Corpus Christi Art League; Corpus Christi Art Guild; American Artist Professional League; Mural Painters of Texas; Southwestern Sculpture Society; New Orleans Art Association; South Texas Art League; Southern States Art League; National League of American Pen Women came after the Washington, D.C..  

Work: Montgomery, Alabama MFA; Del Mar College, Corpus Christi; Corpus Christi Art Foundation.